Identification, characterization and functional analysis of novel protein binding partners of the cell recognition molecule L1 and the polysialylated neural cell adhesion molecule in mouse (Mus musculus

Morphometrical Study of Polysialylated Neural Cell Adhesion Molecule Positive Cells in Rat Pups Hippocampus Following Induction of Seizure during Pregnancy

Background:The polysialylated neural cell adhesion molecule (PSA-NCAM) is expressed in developing brain. Fetal brain damage is caused by different conditions such as seizure and hypoxia. The present study was designed to investigate the effect of maternal seizures on the number of PSA-NCAM positive cells in pup's hippocampus. Methods: Female Wistar rats were divided into four groups: (a) kindle...

Murine neural stem cells engineered to express the neural adhesion molecule L1 under the control of the human GFAP promoter promote functional recovery after transplantation in a mouse spinal cord injury model in Mus musculus (Linneaus, 1758) DISSERTATION Von

Functional effects of transplanted embryonic stem cell-derived neural aggregates overexpressing the neural cell adhesion molecule L1 in the MPTP model of Parkinson's disease and in a spinal cord injury model in Mus musculus (Linnaeus, 1758)

Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3)

Objective(s): As T-cell immunoglobulin and mucin domain 3 (TIM-3) is an immune regulatory molecule; its blocking or stimulating could alter the pattern of immune response towards a desired condition. Based on the unique features of nanobodies, we aimed to construct an anti-TIM-3 nanobody as an appropriate tool for manipulating immune responses for future therapeutic purposes. Materials and Meth...

Radiation-induced expression of platelet endothelial cell adhesion molecule-1 in cerebral endothelial cells

Background: Radiation-induced molecular changes on the endothelial surface of brain arteriovenous malformations (AVM) may be used as markers for specific vascular targeting agents. In this study, we examined the level of expression of platelet endothelial cell adhesion molecule-1 (PECAM-1) on brain endothelial cell surface after radiation treatment, with the aim of targeting the radiation-induc...